In a large bowl, combine the ground beef, salt, pepper, garlic powder, onion powder, smoked paprika, and chili powder.
Form the mixture into four patties, each of them about 4 ounces in weight, 3.5 inches in diameter, and ½ inch thick.
Preheat a grill or a grill pan on medium-high heat. Lightly brush the grill with oil.
Make a shallow dimple in the center of each patty to help the burgers cook evenly and maintain their shape.
Cook the burgers, dimpled side up, for 4 minutes. Turn and cook them on the other side, about 3 more minutes for medium doneness. (See notes).
Serve immediately.
Video
Notes
The cooking time is just a guideline. How long you need to grill will ultimately depend on how hot your grill is, the thickness of the patties, and your desired level of doneness.
Make ahead: Once you've shaped the burgers, you can grill them immediately or cover and refrigerate them for a few hours. I often shape them in the morning and grill them at dinnertime.
The USDA recommends cooking ground meats to an internal temperature of 160°F.
I use a lean ground beef mixture, 85% lean and 15% fat. I wouldn't go any leaner than that, or the patties will be dry and crumbly.
If you'd like to make cheeseburgers, top each burger patty with a slice of your favorite cheese during the last minute of grilling. Cover the grill or grill pan so that the cheese can melt. Alternatively, finish cooking the burgers, top them with cheese, and briefly microwave them to melt the cheese, about 30 seconds for 4 burgers.
You can keep the leftovers in an airtight container in the fridge for 3-4 days. Reheat them in the microwave, covered, at 50% power. Once completely cool, you can also freeze the cooled burgers in freezer bags for up to three months.